An eight years old female Labrador dog was presented with a history of diffuse swelling in the submandibular region. The mass was firm with no pain on palpation. Fine needle aspiration cytology (FNAC) revealed spindle shaped to pleomorphic neoplastic cells with brown to black pigments. The mass was then surgically excised. Histopathology section revealed cells with melanin pigment with round to oval nuclei. Immunohistochemical study showed positive expression for vimentin, S100 and Melan A and no expression for cytokeratin. Based on above findings the mass was confirmed as melanoma. | Cytological histopathological and immunohistohemical study of canine melanoma
