The optimized patch containing FEL-TEA and 10% Azone had significantly higher skin permeation amount (P Furthermore, the in vitro skin permeation results of FEL-TEA patch was found to have a good correlation with the in vivo absorption results in rabbit. These findings indicated that a combination of ion-pair and chemical enhancer strategy could be useful in developing a novel transdermal patch of FEL. | Nội dung Text Design and evaluation of a novel felbinac transdermal patch Combining ion-pair and chemical enhancer strategy