In this paper, the flow shop with blocking and sequence and machine dependent setup time problem aiming to minimize the makespan is studied. Two mixed-integer programming models are proposed (TNZBS1 and TNZBS2) and two other mixed-integer programming models, originally proposed for the no setup problem, are adapted to the problem. Furthermore, an Iterated Greedy algorithm is proposed for the problem. | Solving the permutation flow shop problem with blocking and setup time constraints