In the present study methicillin resistance bacteria was recorded highest compared to other antibiotics and also this is the first report of the occurrence of clinical isolates such as Klebsiella pneumonia and Klebsiella oxytoca with multi drug resistance in aquatic environment including in fish, suggesting the rapid spread of isolates and AMR genes between environments. The study revealed that imprudent use of antibiotics in hospital and release of the waste without prior treatment may have led to the dissemination of resistance from terrestrial to aquatic organism. | Identification and characterization of methicillin resistant bacterial isolates from fish and shellfish collected from cochin backwaters Kerala India