Retinoid signalling is crucial to vertebrate embryonic development. The Cyp26B1 is one of the key catabolic enzymes, involved in the inactivation of all-trans retinoic acid and helps in the maintaining of retinoic acid availability for retinoid signalling. In the present study, for the first time, we cloned and characterized the full coding sequence of Cyp26B1 gene in Clarias magur. The full-length cDNA sequence of Cyp26B1 gene was 1782 bp (ORF 1533 bp) encoding 511 amino acids. Signal peptide analysis revealed that Cyp26B1 is a secretory protein as reported in other vertebrates. The hydropathy profile predicted that Cyp26B1 is hydrophilic in nature. | Molecular cloning of retinoic-acid metabolizing cytochrome P450 26B1 Cyp26B1 and expression analysis during different reproductive phase in clarias magur Hamilton 1822
