In this study, in-vitro experiments were performed using a total of 24 porcine motion segments. The harvested specimens were assigned to prolong and 2 different cyclic loadings. Both disc deformations and water contents were measured to investigate how the mode and rate of loading affect the response of intervertebral disc. | Time-dependent response of intact intervertebral disc In Vitro and In-Silico study on the effect of loading mode and rate Engineering Solid Mechanics 3 2015 51-58 Contents lists available at GrowingScience Engineering Solid Mechanics homepage esm Time-dependent response of intact intervertebral disc In Vitro and In-Silico study on the effect of loading mode and rate Mohammad Nikkhoo a b Ya-Wen Kuo b Yu-Chun Hsub Kinda Khalafc Mohammad Haghpanahid Mohamad Parnianpoure and Jaw-Lin Wangb a Department of Biomedical Engineering Science and Research Branch Islamic Azad University Tehran Iran b Institute of Biomedical Engineering College of Medicine and Engineering National Taiwan University Taipei Taiwan c Department of Biomedical Engineering Khalifa University of Science Technology and Research Abu Dhabi UAE d School of Mechanical Engineering Iran University of Science and Technology Tehran Iran e Department of Industrial amp Manufacturing University of Wisconsin Milwaukee USA ARTICLE INFO ABSTRACT Article history The investigation of dynamic response of intervertebral disc is beneficial for the development Received March 6 2014 of new synthetic and engineered tissues for treating diseased or injured disc. There are limited Accepted 28 November 2014 experimental studies on comparing the effect of loading mode and rate on global response of Available online intervertebral disc. In this study in-vitro experiments were performed using a total of 24 28 November 2014 porcine motion segments. The harvested specimens were assigned to prolong and 2 different Keywords Porcine intervertebral disc cyclic loadings. Both disc deformations and water contents were measured to investigate how Time-dependent response the mode and rate of loading affect the response of intervertebral disc. In parallel a backward Poroelastic FE model FE poroelastic model combined with in-vitro experiments were used to find the material Creep properties of intervertebral discs. The
