The production and accumulation of pathogenesis-related proteins (PR proteins) in plants in response to biotic or abiotic stresses is well known and is considered as a crucial mechanism for plant defense. A pathogenesis-related protein 4 cDNA was identified from a cacao-Moniliophthora perniciosa interaction cDNA library and named TcPR-4b. | The pathogenesis-related protein PR-4b from Theobroma cacao presents RNase activity Ca2 and Mg2 dependent-DNase activity and antifungal action on Moniliophthora perniciosa