The study revealed that the tested compounds are moderate UVB absorbers, but could be used to augment the effect of other photoprotective agents. Their SPF values were in the range from to for salicylates 3a-d and from to for vanillates. | Synthesis and photoprotective properties of new salicylic and vanillic acid derivatives Current Chemistry Letters 6 2017 125 134 Contents lists available at GrowingScience Current Chemistry Letters homepage Synthesis and photoprotective properties of new salicylic and vanillic acid derivatives Alicja Wodnicka and Elżbieta Huzar West Pomeranian University of Technology Szczecin Faculty of Chemical Technology and Engineering Institute of Organic Chemical Technology Al. Piastów 42 71-065 Szczecin Poland CHRONICLE ABSTRACT Article history A simple one-step procedure for synthesis of new derivatives of phenolic acids was developed. Received January 2 2017 As the starting materials salicylic acid vanillic acid and alkyl haloalkanoates were applied. Received in revised form The reactions were carried out in N N-dimethylformamide DMF in the presence of anhydrous March 1 2017 potassium carbonate. Conditions for regioselective synthesis of target compounds were Accepted March 21 2017 established. The esters 3a-h were obtained in great yields and were characterized by MS 1H Available online and 13C NMR spectra. Their photoprotective activity was evaluated in vitro by March 21 2017 spectrophotometric method. The study revealed that the tested compounds are moderate UVB Keywords absorbers but could be used to augment the effect of other photoprotective agents. Their SPF Phenolic acids derivatives Salicylates values were in the range from to for salicylates 3a-d and from to for Vanillates vanillates. Photoprotection Sun protection factor SPF 2017 Growing Science Ltd. All rights reserved. 1. Introduction People outdoors are exposed to solar radiation which consists of 56 of infrared light photons 39 of visible light and 5 of UV Despite the fact that UV radiation is a minority stream of light that reaches the Earth s surface it can cause the harmful effects on the human body. Excessive exposure to ultraviolet radiation is a .
