A novel one-pot, solvent-free method for the synthesis of dithiocarbamates was developed through the reaction of corresponding alkyl halides, amines and carbon disulfide employing catalytic amount of benzyl trimethyl ammonium hydroxide (Triton-B). | Triton-B catalyzed efficient and solvent-free approach for the synthesis of dithiocarbamates Current Chemistry Letters 6 2017 143 150 Contents lists available at GrowingScience Current Chemistry Letters homepage Triton-B catalyzed efficient and solvent-free approach for the synthesis of dithiocarbamates Sadaf Zaidia Amit K. Chaturvedib Nidhi Singha and Devdutt Chaturvedia c a Department of Applied Chemistry Amity School of Applied Sciences Amity University Uttar Pradesh AUUP Lucknow Campus Lucknow-226028 U. P. India b Department of Chemistry J. S. University Shikohabad-283135 Firozabad U. P. India. c Department of Chemistry School of Physical amp Material Sciences Mahatma Gandhi Central University Motihari-845401 East Champaran Bihar India CHRONICLE ABSTRACT Article history A novel one-pot solvent-free method for the synthesis of dithiocarbamates was developed Received November 14 2016 through the reaction of corresponding alkyl halides amines and carbon disulfide employing Received in revised form catalytic amount of benzyl trimethyl ammonium hydroxide Triton-B . The reaction conditions June 20 2017 are milder with extremely simple work-up procedures than the reported methods afforded high Accepted July 4 2017 yields 82-98 of the desired products. Available online July 5 2017 Keywords Amines Alkyl halides Carbon disulfide Triton-B Dithiocarbamates 2017 Growing Science Ltd. All rights reserved. 1. Introduction Organic dithiocarbamates have extensively been used as agrochemicals 1 pharmaceuticals 2intermediates in organic synthesis 3 protection of amino groups in peptide chemistry 4 linkers in solid phase organic synthesis 5 radical precursors in free-radical chemistry6and synthesis of ionic Furthermore different transition metal complexes of dithiocarbamates have been synthesized for various studies primarily because of their applications as organic recent years dithiocarbamates have been emerged as a novel .
