A clean and efficient, mediated in water and assisted by ultrasound method for the synthesis of a series of N-substituted 1-amino-3-ferrocenyl-3-oxoprop-1-enes starting from acetyl ferrocene was developed. | Ultrasound assisted synthesis of 1-amino-3-ferrocenyl-3-oxoprop-1-enes Current Chemistry Letters 7 2018 35 44 Contents lists available at GrowingScience Current Chemistry Letters homepage Ultrasound assisted synthesis of 1-amino-3-ferrocenyl-3-oxoprop-1-enes Jai N. Vishwakarma Shilpika Khanikar Utpalparna Kalita Shunan Kaping and Madhushree Ray Organic Research Lab. Department of Chemical Science Assam Don Bosco University Tapesia Campus Tapesia Gardens Kamarkuchi Sonapur- 782402 Assam India CHRONICLE ABSTRACT Article history A clean and efficient mediated in water and assisted by ultrasound method for the synthesis of Received December 22 2017 a series of N-substituted 1-amino-3-ferrocenyl-3-oxoprop-1-enes starting from acetyl Received in revised form ferrocene was developed. Our approach offers shortening of the reaction time under the mild March 20 2018 reaction conditions and easy work up procedure. Accepted March 25 2018 Available online March 25 2018 Keywords Enaminones Michael addition Nucleophilic substitution Crystal structure 2018 Growing Science Ltd. All rights reserved. 1. Introduction Studies on the chemistry of ferrocene1-3 have attracted the interest of many scientists and research groups due to its applications in material science 4 asymmetric synthesis4 and 6 The ferrocene derivatives exhibit also an antiplasmodial 7-9 antitumor 10 and DNA cleaving12 activities have an antiproliferative effects on the MCF7 cell lines 11 activity and have chemotherapeutic action on drug- resistant 13 On the other hand enaminones are important building blocks in the synthesis of many heterocyclic compounds14 and many therapeutic antitumor 15 antimicrobial 15-17 anticonvulsant 18 anti- inflammatory 19 analgesic 19 ulcerogenic Keeping in view the biological importance of enaminones 18 21 we have recently reported22 the synthesis of Z -3-adamantyl-1-aryl-prop but-2-en-1- ones which were tested for anti-inflammatory .
