An ecofriendly methods for the synthesis of medicinally important class of heterocyclic scaffold, pyrazole 4-carbonitrile derivatives by one pot three component reaction of malononitrile, phenyl hydrazine and aromatic aldehyde has been achieved at room temperature. | NaCl a facile environmentally benign catalyst for the synthesis of pyrazole 4-carbonitrile in aqueous media Current Chemistry Letters 7 2018 57 64 Contents lists available at GrowingScience Current Chemistry Letters homepage NaCl a facile environmentally benign catalyst for the synthesis of pyrazole 4- carbonitrile in aqueous media Amol Khandebharada Swapnil Sardaa Mahesh Sonia Charansingh Gillb Pravin Kulkarnia and Brijmohan Agrawala a Department of Chemistry J. E. S. College Jalna MS India b Department of Chemistry Dr. Aurangabad MS India CHRONICLE ABSTRACT Article history An ecofriendly methods for the synthesis of medicinally important class of heterocyclic Received December 22 2017 scaffold pyrazole 4-carbonitrile derivatives by one pot three component reaction of Received in revised form malononitrile phenyl hydrazine and aromatic aldehyde has been achieved at room March 21 2018 temperature. Greener protocols of reaction are followed by using sodium chloride to accelerate Accepted March 25 2018 the reaction in aqueous media. Present methodology is a condition based divergence on Available online synthesis of pyrazole by using simple salts which offers several advantages like use of March 25 2018 aqueous media and high yield of product along with short reaction time simple work up Keywords procedure no waste or by products avoid the use of heavy metals or nanoparticles are the Aromatic aldehyde Malononitrile Phenyl hydrazine fascinating characteristics of reaction. Pyrazole 4-carbonitrile Sodium chloride 2018 Growing Science Ltd. All rights reserved. 1. Introduction Organic chemists have been always demanded to mimic the principals of natural surroundings to develop new methodologies so as to achieve the aim of green chemistry. In this era of developing eco- friendly tools chemists are on the way of maximizing the efficiency of reaction by using those raw materials which are produced by nature and whose use is in the .
