An efficient, three-component, catalyst free synthesis of dipyrazolo[1,5-a:3',4'-d]pyramid scaffolds has been carried out using 3-methyl-1H-pyrazol-5(4H)-one (1), 5-amino pyarazole (2a-b) and substituted aromatic aldehydes. | Facile multi-components one-pot synthesis of dipyrazolo 1 5-a 3 4 -d pyrimidine as potent bioactive scaffolds Current Chemistry Letters 7 2018 111 120 Contents lists available at GrowingScience Current Chemistry Letters homepage Facile multi-components one-pot synthesis of dipyrazolo 1 5-a 3 4 -d pyrimidine as potent bioactive scaffolds Ravindra M. Gola and Vijaykumar M. Barota a P. G. Center in Chemistry Smt. S. M. Panchal Science College Talod Gujarat India CHRONICLE ABSTRACT Article history An efficient three-component catalyst free synthesis of dipyrazolo 1 5-a 3 4 -d pyramid Received June 20 2018 scaffolds has been carried out using 3-methyl-1H-pyrazol-5 4H -one 1 5-amino pyarazole Received in revised form 2a-b and substituted aromatic aldehydes. The reaction underwent cyclocondensation reaction August 27 2018 in reflux condition with moderate to good 62 90 yields. The twenty newly prepared Accepted October 30 2018 molecules were analyzed by means of 1H amp 13C NMR Mass and IR spectroscopies and their Available online activities against the bacterial and fungal strains were screened. Some of tested compounds October 30 2018 have shown excellent antibacterial activities while another four were found to have good Keywords antifungal activity. Dipyrazolo 1 5-a 3 4 - d pyrimidine Multi-component reaction Catalyst free Antibacterial Antifungal 2018 by the authors licensee Growing Science Canada. 1. Introduction Pyrimidine scaffold is found in several naturally occurring compounds and they make the core structures of many biologically active scaffolds and much more pharmaceutical industrial 2 For the most part significant fused dipyrazoloes is diprazolopyrimidine derivative which acquires a range of biological potent The MCRs Multi-components reaction approach is more convenient in comparison to conventional synthesis because of flexibility and atom-efficient We used the MCRs for an optimization of a .
