A simple, efficient and general method for the synthesis of 4H-pyrans is established through a multi component cyclocondensation of aromatic aldehydes, malononitrile and ethyl acetoacetate or acetyl acetone using snail shell as a natural catalyst. | Snail shell as a new natural and reusable catalyst for synthesis of 4H-Pyrans derivatives Current Chemistry Letters 5 2016 99 108 Contents lists available at GrowingScience Current Chemistry Letters homepage Snail shell as a new natural and reusable catalyst for synthesis of 4H-Pyrans derivatives Zakaria Benzekria Houdda Serrara Said Boukhris a Brahim Sallekb and Abdelaziz Souizia a Laboratory of Organic Chemistry Organometallic and Theoretical. Faculty of Sciences Ibn Tofaïl University BO 133 14000 Kenitra Morocco b Laboratoire d Agroressources et Génie des Procédés. Faculté des Sciences Université Ibn Tofaïl 14000 Kenitra Morocco CHRONICLE ABSTRACT Article history A simple efficient and general method for the synthesis of 4H-pyrans is established through a Received October 21 2015 multi component cyclocondensation of aromatic aldehydes malononitrile and ethyl Received in revised form acetoacetate or acetyl acetone using snail shell as a natural catalyst. In this method the snail December 20 2015 shell was used as green and reusable natural catalyst. Excellent yields short reaction times and Accepted 7 April 2016 availability of the catalyst are the advantages of this method. Available online 7 April 2016 Keywords Heterogeneous catalysis 4H-pyrans Snail shell Natural catalysts Green catalysts 2016 Growing Science Ltd. All rights reserved. 1. Introduction Compared with classical methods the heterogeneous catalysis solid-liquid has been shown to have desirable effects on reactions performance such as good yields short reaction times easier work-up procedure formation of pure products in milder conditions and waste minimization. In addition introduction of clean procedures utilizing eco-friendly green catalysts has attracted great attention of Thus development of a mild inexpensive and reusable catalyst for synthesis of organic compounds still remains an attractive goal for researchers. 4H-Pyran derivatives occupy an important place
