Mangroves plants and their endophytes represent a natural source of novel and bioactive compounds. In our ongoing research on mangrove endophytes from the Panamanian Pacifc Coast, we have identified several bio‑ active endophytic fungi. From these organisms, an isolate belonging to the genus Zasmidium (Mycosphaerellaceae) showed of inhibition against α-glucosidase enzyme in vitro | α-Glucosidase inhibitors from a mangrove associated fungus Zasmidium sp. strain EM5-10