Rhodanines and quinazolinones have been reported to possess various pharmacological activities. A novel series of twenty quinazolinone-based rhodanines were synthesized via Knoevenagel condensa‑ tion between 4-[3-(substitutedphenyl)-3,4-dihydro-4-oxoquinazolin-2-yl)methoxy]substituted-benzaldehydes and rhodanine. | Synthesis and anticancer activity of novel quinazolinone based rhodanines