1,2,4-Triazoles and 1,2,3-triazoles have gained significant importance in medicinal chemistry. This study describes a green, efficient and quick solvent free click synthesis of new 1,2,3-triazole-4,5-diesters carrying a lipophilic side chain via 1,3-dipolar cycloaddition of diethylacetylene dicarboxylate with different surfactant azides. | Design synthesis in silico and in vitro antimicrobial screenings of novel 1 2 4-triazoles carrying 1 2 3-triazole scaffold with lipophilic side chain tether