Thiophene derivatives have shown versatile pharmacological activities. The Suzuki reaction proved a convenient method for C–C bond formations in organic molecules. In the present research work novel derivatives of 2,5-dibromo3-methylthiophene (3a–k and 3l–p) has been synthesized, via Suzuki coupling reaction in low to moderate yields. | Palladium 0 catalyzed Suzuki cross-coupling reaction of 2 5-dibromo-3-methylthiophene Selectivity characterization DFT studies and their biological evaluations