A series of azinesulfonamide derivatives of long-chain arylpiperazines with variable-length alkylene spacers between sulfonamide and 4-arylpiperazine moiety is designed, synthesized, and biologically evaluated. | Structural determinants infuencing halogen bonding A case study on azinesulfonamide analogs of aripiprazole as 5-HT1A 5-HT7 and D2 receptor ligands