Tuberculosis has proved harmful to the entire history of mankind from past several decades. Decaprenyl-phosphorylribose 2′-epimerase (DprE1) is a recent target which was identified in 2009 but unfortunately it is neither explored nor crossed phase II. | Decaprenyl-phosphoryl-ribose 2 -epimerase DprE1 Challenging target for antitubercular drug discovery