Dioxoisoindolines have been included as a pharmacophore group in diverse drug-like molecules with a wide range of biological activity. Various reports have shown that phthalimide derivatives are potent inhibitors of AChE, a key enzyme involved in the deterioration of the cholinergic system during the development of Alzheimer’s disease. | Crystal structure DFT calculations and evaluation of 2 2 3 4 dimethoxyphenyl ethyl isoindoline 1 3 dione as AChE inhibitor