Nitrogen heterocyclic rings and sulfonamides have attracted attention of several researchers. A series of regioselective imidazole-based mono- and bis-1,4-disubstituted-1,2,3-triazole-sulfonamide conjugates 4a–f and 6a–f were designed and synthesized. | Design synthesis ADME prediction and pharmacological evaluation of novel benzimidazole 1 2 3 triazole sulfonamide hybrids as antimicrobial and antiproliferative agents