The study aims to develop simple, sensitive, and selective methods for detecting methylphenidate in its bulk, dosage form and human urine. Sensing materials include β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD), and 4-tertbutylcalix[8] arene as ionophores or electroactive materials have been used for construction of sensors 1, 2, and 3, respectively. | New potentiometric sensors for methylphenidate detection based on host guest interaction