This paper describes the application of response surface methodology (RSM) to develop a miniaturized metal organic framework based pipette-tip solid phase extraction for the extraction of malachite green (MG), rhodamine B (RB), methyl orange (MO) and acid red 18 (AR) dyes from seawater samples and their determination by high performance liquid chromatography. | Application of response surface methodology for optimization of metal organic framework based pipette-tip solid phase extraction of organic dyes from seawater and their determination with HPLC