Sigma (σ) receptors are membrane-bound proteins characterised by an unusual promiscuous ability to bind a wide variety of drugs and their high affinity for typical neuroleptic drugs, such as haloperidol, and their potential as alternative targets for antipsychotic agents. | 4-aroylpiperidines and 4- α-hydroxyphenyl piperidines as selective sigma-1 receptor ligands Synthesis preliminary pharmacological evaluation and computational studies