New ruthenium(III) complexes with 3-(Benzothiazol-2-yliminomethyl)-phenol (HL) ligand have been synthesized and characterized with the aid of elemental analysis, IR, electronic, and electron paramagnetic resonance spectroscopic techniques. | Biological investigations of ruthenium III 3- Benzothiazol-2-liminomethyl -phenol Schiff base complexes bearing PPh3 AsPh3 coligand Current Chemistry Letters 8 2019 145 156 Contents lists available at GrowingScience Current Chemistry Letters homepage Biological investigations of ruthenium III 3- Benzothiazol-2-liminomethyl - phenol Schiff base complexes bearing PPh3 AsPh3 coligand Sathiyaraj Subbaiyana and Indhumathi Ponnusamyb a Department of Chemistry Dr. . Arts and Science College Coimbatore - 641048 India b Department of Chemistry Shri Nehru Maha Vidyalaya College of Arts amp Science Coimbatore - 641050 India CHRONICLE ABSTRACT Article history New ruthenium III complexes with 3- Benzothiazol-2-yliminomethyl -phenol HL ligand Received September 23 2018 have been synthesized and characterized with the aid of elemental analysis IR electronic and Received in revised form electron paramagnetic resonance spectroscopic techniques. The binding mode of the ligand April 18 2019 and complexes with DNA and their ability to bind DNA have been investigated by UV-vis Accepted April 18 2019 absorption titration. In addition the ligand and complexes have been subjected to antioxidant Available online activity tests which showed that HL and its ruthenium III complexes possess significant April 18 2019 scavenging effect against DPPH and OH radicals. Cytotoxic activities of the ligand and Keywords ruthenium III complexes showed that the ruthenium III complexes exhibited more effective Ruthenium III complex Schiff base cytotoxic activity against HeLa and MCF-7 cells than the corresponding ligand. DNA-binding Scavenging activity In vitro cytotoxicity 2019 by the authors licensee Growing Science Canada. 1. Introduction It is familiar that medicinal inorganic chemistry is a multidisciplinary field combining elements of chemistry pharmacology toxicology and biochemistry. Transition metal complexes that are able of cleave DNA under physiological environment
