In this work, the Fe3O4@SiO2@AMBI/Cu nanocatalyst was synthesized and used as a well-organized magnetic nanocatalyst for the click reaction. This nanocatalyst has effectively catalyzed the cyclization of terminal alkynes and sodium azide with aryl iodide/benzyl halide for the formation of 1,4-disubstituted 1,2,3-triazoles under mild reaction conditions with good to high yields in low reaction time. | 2- Aminomethyl benzimidazole Cu2 immobilized on Fe3O4@SiO2 a convenient magnetic nanocatalyst for click reaction of aryl iodide benzyl halide sodium azide and terminal alkyne Current Chemistry Letters 9 2020 9 18 Contents lists available at GrowingScience Current Chemistry Letters homepage 2- Aminomethyl benzimidazole Cu2 immobilized on Fe3O4@SiO2 a convenient magnetic nanocatalyst for click reaction of aryl iodide benzyl halide sodium azide and terminal alkyne Mostafa Mehdipoura and Mohammad Reza Khodabakhshia a Applied Biotechnology Research Center Baqiyatallah University of Medical Sciences Vanak Square Mollasadra Ave. . Box 1435915371 Tehran Iran CHRONICLE ABSTRACT Article history In this work the Fe3O4@SiO2@AMBI Cu nanocatalyst was synthesized and used as a well- Received May 29 2019 organized magnetic nanocatalyst for the click reaction. This nanocatalyst has effectively Received in revised form catalyzed the cyclization of terminal alkynes and sodium azide with aryl iodide benzyl halide June 11 2019 for the formation of 1 4-disubstituted 1 2 3-triazoles under mild reaction conditions with good Accepted June 16 2019 to high yields in low reaction time. Available online June 16 2019 Keywords Click reaction Copper 2- Aminomethyl benzimidazole dihydrochloride Fe3O4@SiO2 1 4-disubstituted 1 2 3-triazoles 2020 by the authors licensee Growing Science Canada. 1. Introduction The term bioorthogonal chemistry was born in 2003 by Bertozzi1. Bioorthogonal chemistry is about designing reactions that can be achieved in a biological environment and proceeded in living systems. This kind of reactions are posing great biocompatibility and selectivity also opening new approaches for new innovations in biology by feasible various bond formations in biological systems. From this kind of reactions click reaction should be mentioned. This reaction was defined in 2001 by Sharpless as an insensitive and easy performing reaction by accessible reagents. .
