In this study, a green and practical approach towards Hantzsch dihydropyridine synthesis of acridine-1,8-diones is introduced. Via the mentioned protocol, the one-pot condensation reaction of structurally diverse aromatic aldehydes, dimedone and NH4OAc was promoted by microwave radiation at solvent and catalyst-free conditions. | Microwave-promoted three-component Hantzsch synthesis of acridinediones under green conditions Current Chemistry Letters 9 2020 71 78 Contents lists available at GrowingScience Current Chemistry Letters homepage Microwave-promoted three-component Hantzsch synthesis of acridinediones under green conditions Behzad Zeynizadeh and Masumeh Gilanizadeh Faculty of Chemistry Urmia University Urmia 5756151818 Iran CHRONICLE ABSTRACT Article history In this study a green and practical approach towards Hantzsch dihydropyridine synthesis of Received January 2 2017 acridine-1 8-diones is introduced. Via the mentioned protocol the one-pot condensation Received in revised form reaction of structurally diverse aromatic aldehydes dimedone and NH4OAc was promoted by March 1 2017 microwave radiation at solvent and catalyst-free conditions. Consequently acridinedione Accepted April 21 2017 products were produced in 81 97 yields within 3 8 min. The current protocol represents the Available online prominent advantages in terms of the using a simple synthetic procedure short reaction times July 27 2019 mild reaction conditions high yield of the products as well as omission of hazardous and cost- Keywords effective organic solvents reagents. Acridinediones Arylaldehydes Dimedone Hantzsch synthesis Microwave 2020 Growing Science Ltd. All rights reserved. 1. Introduction Multi-component reactions MCRs have been widely utilized as an efficient synthetic protocol towards preparation of numerous organic and pharmacological This method bring an economical and environmental-friendly approach via the one-pot condensation reaction of three or more components in a one- step to produce new compounds containing the starting materials in their skeletal arrangement. 2 Acridinediones are one of the important class of nitrogen heterocyclic compounds involving the ring of 1 4- dihydropyridine 1 4-DHP . These materials are considered as effective pharmaceutical agents .
