This study aimed to optimize additional carrier concentration for spray drying of Pouzolzia zeylanica extract. Response Surface Methodology (RSM) with central composite design (CCD) was applied for optimization and investigation of the influence of maltodextrin (5ö15%, w/v) and carrageenan gum (, w/v) concentration on the physicochemical characteristics of spray dried powder (bioactive compounds, moisture content as well as particle size distribution). | Optimization of maltodextrin and carrageenan gum concentration added in spray drying process of Pouzolzia zeylanica extract response surface methodology Nong Lam University Ho Chi Minh City 77 Optimization of maltodextrin and carrageenan gum concentration added in spray drying process of Pouzolzia zeylanica extract by response surface methodology Tan D. Nguyen1 amp Thuy M. Nguyen2 1 Department of Food Technology An Giang University An Giang Vietnam 2 Department of Food Technology Can Tho University Can Tho Vietnam ARTICLE INFO ABSTRACT Research paper Pouzolzia zeylanica is a kind of medicinal plant which is generally cultivated in Mekong Delta region. It owns many bioactive compounds Received January 02 2018 that are known to possess antioxidant antimicrobial and anticar- Revised April 20 2018 cinogenic properties. This study aimed to optimize additional carrier Accepted May 24 2018 concentration for spray drying of Pouzolzia zeylanica extract. Response Surface Methodology RSM with central composite design CCD Keywords was applied for optimization and investigation of the influence of maltodextrin 5ö15 w v and carrageenan gum w v Carrageenan concentration on the physicochemical characteristics of spray dried powder bioactive compounds moisture content as well as particle size Maltodextrin distribution . The results showed that the optimum concentrations of Pouzolzia zeylanica maltodextrin and carrageenan gum were w v and w v Response Surface Methodology respectively. At these optimal conditions the anthocyanin flavonoid Spray drying polyphenol tannin moisture content and particle size of obtained spray dried powder were mg cyanidin-3-glycoside equivalents CE 100 g Corresponding author mg quercetin equivalents QE g gallic acid equivalents GAE g mg tannic acid equivalents TAE g and Nguyen Duy Tan µm respectively. Email ndtan@ Cited as Nguyen T. D. amp Nguyen T. M. 2018 . Optimization of maltodextrin .