α-tocopherol (AT) and γ-tocotrienol (GT3) are vitamin E isoforms considered to have potential chemopreventive properties. AT has been widely studied in vitro and in clinical trials with mixed results. The latest clinical study (SELECT trial) tested AT in prostate cancer patients, determined that AT provided no benefit, and could promote cancer. | Upregulation of pERK and c-JUN by γtocotrienol and not α-tocopherol are essential to the differential effect on apoptosis in prostate cancer cells
