Brain metastases from sarcomatous lesions pose a management challenge owing to their rarity and the histopathological heterogeneity. Prognostic indices such as the Graded Prognostic Assessment (GPA) index have been developed for several primary tumour types presenting with brain metastases (. lung, breast, melanoma), tailored to the specifics of different primary histologies and molecular profiles. | Development of a disease-specific graded prognostic assessment index for the management of sarcoma patients with brain metastases Sarcoma-GPA