yndecan-1 (SDC-1) is a crucial membrane proteoglycan, which is confirmed to participate in several tumor cell biological processes. However, the biological significance of SDC-1 in colorectal carcinoma is not yet clear. | Syndecan-1 suppresses cell growth and migration via blocking JAK1 STAT3 and Ras Raf MEK ERK pathways in human colorectal carcinoma cells