Cranial radiotherapy (cRT) can induce hormonal deficiencies as a consequence of significant doses to the hypothalamic-pituitary (HP) axis. In contrast to profound endocrinological follow-up data from survivors of childhood cancer treated with cRT, little knowledge exists for adult cancer patients. | Are hypothalamic- pituitary HP axis deficiencies after whole brain radiotherapy WBRT of relevance for adult cancer patients a systematic review of the literature