Pyroptosis belongs to a novel inflammatory programmed cell death pathway, with the possible prognosis of endometrial cancer related to the terminal protein GSDMD. Hydrogen exerts a biphasic effect on cancer by promoting tumor cell death and protecting normal cells, which might initiate GSDMD pathway-mediated pyroptosis. | Hydrogen inhibits endometrial cancer growth via a ROS NLRP3 caspase-1 GSDMD-mediated pyroptotic pathway