Oral cancer has been estimated as the sixth most frequent solid cancer all over the world, in which tongue squamous cell carcinoma (TSCC) is the most common type of oral cancers. However, the mechanism of TSCC metastasizing to lymph node and distant sites has not been completely understood. | Numb inhibits epithelial-mesenchymal transition via RBP-Jκ-dependent Notch1 PTEN FAK signaling pathway in tongue cancer