The spine is the most frequent location of bone metastases. Local treatment aims at palliation of pain and, given the increased likelihood of long-term cancer survival, at local control. Kyphoplasty and intraoperative radiotherapy (Kypho-IORT) provided instantaneous pain relief in 70% of patients at the first day after the intervention and resulted in local control rates of > 93% at 1 year in a recently conducted phase I/II trial. | Combined kyphoplasty and intraoperative radiotherapy Kypho-IORT versus external beam radiotherapy EBRT for painful vertebral metastases - a randomized phase III study
