Mutated BRCA1/2 genes are associated with hereditary breast and ovarian cancer (HBOC). So far most of the identified BRCA1/2 pathogenic variants are single nucleotide variants (SNVs) or insertions/deletions (Indels). | Comprehensive mutation detection of BRCA1 2 genes reveals large genomic rearrangements contribute to hereditary breast and ovarian cancer in Chinese women