The aim of this study was to prospectively evaluate the feasibility, tolerability, and pharmacokinetics of selective transarterial chemoembolization (TACE) with irinotecan-loaded 40 μm microspheres combined with systemic FOLFIRI for colorectal liver metastases refractory to oxaliplatin regimen. | Selective TACE with irinotecan-loaded 40 μm microspheres and FOLFIRI for colorectal liver metastases Phase I dose escalation pharmacokinetic study