Current advancements in neoadjuvant therapy and total mesorectal excision have engendered increased local control. However, the survival benefit of preoperative radiotherapy (RT; 5 × 5 Gy) in rectal cancer patients remains inadequate, primarily because of systemic recurrence. | Monthly tegafur uracil maintenance for increasing relapse-free survival in ypStage III rectal cancer patients after preoperative radiotherapy radical resection and 12 postoperative chemotherapy cycles A retrospective study