Combination of chemotherapies (fluoropirimidines, oxaliplatin and irinotecan) with biologic drugs (bevacizumab, panitumumab, cetuximab) have improved clinical responses and survival of metastatic colorectal cancer (mCRC). | Cetuximab irinotecan and fluorouracile in fiRst-line treatment of immunologicallyselected advanced colorectal cancer patients The CIFRA study protocol