The CAO/ARO/AIO-94 demonstrated that neoadjuvant chemoradiotherapy (CRT) could decrease the rate of local recurrence rather than distal metastases in advanced rectal cancer. Adjuvant chemotherapy (ACT) can eliminate micrometastasis, and render a better prognosis to rectal cancer. | ACRNaCT trial protocol Efficacy of adjuvant chemotherapy in patients with clinical T3b T4 N rectal Cancer undergoing Neoadjuvant Chemoradiotherapy A pathology-oriented prospective multicenter randomized open-label parallel group clinical trial
