Interleukin-6 (IL-6) is commonly highly secreted in the breast cancer (BrCA) microenvironment and implicated in disease development. In this study, we aimed to determine the role of the IL-6/pSTAT3/HIC1 axis in the breast cancer microenvironment, including in cancer-associated fibroblasts (CAFs) and breast cancer cells. | Tumor suppressor HIC1 is synergistically compromised by cancer-associated fibroblasts and tumor cells through the IL6 pSTAT3 axis in breast cancer