Evolution of multi drug resistant isolates has become rampant in today’s world. The credit of this goes to the incomplete dosage and irrational use of antibiotics. The human brains are now in search of alternate methods. Use of Silver nanoparticles is one amongst them. In the following study, 50 multi-drug resistant clinical isolates of P. aeruginosa acquired from the intensive care units were tested with antibiotics, AgNps and AgNp-antibiotic conjugates. The conjugates were prepared by impregnating 30 µl of AgNps in sterile plain disks and the antibiotic disks separately. | A study of synergistic antibacterial activity of silver nanoparticles with antibiotics against multi-drug resistant pseudomonas aeruginosa in intensive care units of a Tertiary care hospital