Human epidermal growth factor receptor HER3 (ErbB3), especially in association with its relative HER2 (ErbB2), is known as a key oncogene in breast tumour biology. Nonetheless, the prognostic relevance of HER3 remains controversial. NEDD4–1 and NRDP1 are signalling molecules closely related to the degradation of HER3 via ubiquitination. | Clinicopathological and prognostic correlations of HER3 expression and its degradation regulators NEDD4 1 and NRDP1 in primary breast cancer
