Pleomorphic liposarcoma (PLPS) is a rare, heterogeneous and an aggressive variant of liposarcoma. Therefore, individualized therapy is urgently needed. Our recent reports suggest that trabectedin (TRAB) is effective against several patient-derived orthotopic xenograft (PDOX) mouse models. | Trabectedin arrests a doxorubicin-resistant PDGFRA-activated liposarcoma patientderived orthotopic xenograft PDOX nude mouse model