Polo-like kinase 1 (Plk1) is a serine/threonine kinase that is a key regulator of multiple stages of mitotic progression. Plk1 is upregulated in many tumor types including colorectal cancer (CRC) and portends a poor prognosis. | Antitumor activity of the polo-like kinase inhibitor TAK-960 against preclinical models of colorectal cancer