It is frequently asked whether chemotherapy can still play a role in metastatic melanoma considering the effectiveness of the available drugs today, including antiCTLA4/antiPD1 immunotherapy and antiBRAF/antiMEK inhibitors. | The search for a melanoma-tailored chemotherapy in the new era of personalized therapy A phase II study of chemo-modulating temozolomide followed by fotemustine and a cooperative study of GOIM Gruppo Oncologico Italia Meridionale