Orphan nuclear receptors ERRα, ERRβ and ERRγ that belong to NR3B or type IV nuclear receptor family are well studied for their role in breast cancer pathophysiology. Their homology with the canonical estrogen receptor dictates their possible contributing role in mammary gland development and disease. | Estrogen-related receptors alpha beta and gamma expression and function is associated with transcriptional repressor EZH2 in breast carcinoma