A wide range of studies has investigated the diagnostic proficiency of extracellular microRNAs (miRNAs) in hepatocellular cancer (HCC). HCC is expected to increase in Sub-Saharan Africa (SSA), due to endemic levels of viral infection (HBV/HIV), ageing and changing lifestyles. | Circulating microRNA s as a diagnostic tool for hepatocellular carcinoma in a hyper endemic HIV setting KwaZulu-Natal South Africa A case control study protocol focusing on viral etiology