The purpose of this case report is to describe a conjunctiva and eyelid Kaposi’s sarcoma (KS) as the initial manifestation of acquired immunodeficiency syndrome (AIDS), which led to the diagnosis of HIV infection. There are only 3 reported cases of ocular KS as an initial manifestation of HIV infection. | Kaposi s sarcoma of the conjunctiva and the eyelid leads to the diagnosis of human immunodeficiency virus infection a case report