MicroRNAs are small non-protein-coding RNA molecules that regulate gene expression, and have a potential epigenetic role in disease progression and survival of colorectal cancer. In terms of tumor-normal expression differences, many microRNAs exhibit evidence of being up-regulated in some subjects but downregulated in others, or are dysregulated only for a subset of the population. | Identifying factors associated with the direction and significance of microRNA tumor-normal expression differences in colorectal cancer
